It’s an underlying factor (if not key cause) of almost all chronic degenerative diseases.3 While there are multiple factors that can contribute to chronic inflammation, excess oxidative stress is a major trigger.4 In a study published in the journal Drug and Chemical Toxicology, researchers found long-term consumption of aspartame significantly reduced concentrations of glutathione, the body’s “master antioxidant,” in the brain.5. In other words, it may not just be a matter of how much. To put it into perspective, a 150-pound person weighs about 68 kilograms, for which the ADI would be between 2,720 and 3,400 mg of aspartame. Millions of American adults and children consume aspartame daily (often unknowingly). In the study, the researchers showed how the aspartame breakdown byproduct phenylalanine blocks the action of an enzyme (i.e., intestinal alkaline phosphatase) that can prevent obesity, diabetes, and metabolic syndrome. According to the University of Alabama at Birmingham, a single packet of Equal contains 37 mg of aspartame while a 12-ounce can of diet soda contains 200 mg. In fact, it’s why many healthcare practitioners recommend its use to type 2 diabetics. With that in mind, here are some action steps: In general, I think you could make an argument that most people could stand to reduce the amount of “sweet stuff” they eat. Since 1981, when the FDA first approved aspartame—which, by the way, was launched by Monsanto (the same company notorious for the weed killer glyphosate/Roundup, not to mention the dissemination of genetically modified plants and foods)—researchers have debated both its recommended safe amounts and its general safety to organ systems. | Home | FAQ's | Site Map | About | Contact | Terms of Use | Privacy Policy |. 57 packets. RESULTS FEATURED ON THIS WEB SITE MAY BE ATYPICAL. When folks consumed diets containing 25 mg/kg/day aspartame (half the “safe” amount, according to the FDA guidelines) for 8 days, they were more irritable, more depressed, and scored worse on tests of cognitive function.1. Images and information courtesy of the NutraSweet Company. It’s true that the components that make up aspartame (i.e., aspartic acids and phenylalanine) are similar to those found in everyday foods. NutraSweet® is the trade name for one manufacturer's products that contain aspartame (visit https://www.nutrasweet.com for more information). Phenylalanine is involved in neurotransmitter regulation, and aspartic acid is an “excitatory” neurotransmitter. Aspartame may also alter the activity and balance of gut microbes, and it may interfere with the N-methyl D-aspartate (NMDA) receptor, resulting in insulin deficiency or resistance.11 That’s a lot of mumbo jumbo, I know, but the point is that despite being a non-nutritive sugar substitute that doesn’t impact blood glucose, there’s compelling evidence that aspartame may do more harm than good when it comes to glycemic control and variability. (Prices may vary for AK and HI.) The researchers concluded, “Individuals with mood disorders are particularly sensitive to this artificial sweetener, and its use in this population should be discouraged.”7, In a study published in the journal PLOS ONE, researchers from the National Cancer Institute evaluated the connection between soft drink consumption and the risk of depression among a sample of over 260,000 participants in the NIH-AARP Diet and Health Study. As intuitive as that conclusion may seem, however, it doesn’t seem to work that way in the real world. Since aspartame contains phenylalanine, it should not be used by persons with phenylketonuria (PKU), a rare disease. We also observed that replacing sugars with non-caloric artificial sweeteners leads to negative changes in fat and energy metabolism.”. Because it breaks down when heated, aspartame is not recommended for baking. There’s at least a handful of potential reasons why aspartame may be harmful. As a zero-calorie sugar substitute, it seems like it would be a no-brainer that aspartame would help with weight loss. BIOTRUST DISTRIBUTES A PRODUCT LINE MADE WITH NATURAL INGREDIENTS. It is best known under the brand name Equal®. A pink packet is probably going to be filled with saccharin—the oldest artificial sweetener, first discovered in 1878 at Johns Hopkins University.For a while, in the 1980s and 1990s, saccharin fell out of favor, because was linked to some pretty nasty potential negative health effects in 1978. Unless you’re using 90-plus packets of Equal a day or drinking 200-plus ounces of diet soda daily, you shouldn’t have anything to worry about, right? Heat-stable versions of aspartame are under development. This suggests switching from regular to diet soda, for example, may be a case of “out of the frying pan, into the fire.”, According to lead researcher Brian Hoffman, PhD, assistant professor in the department of biomedical engineering at the Medical College of Wisconsin and Marquette University, “In our studies, both sugar and artificial sweeteners seem to exhibit negative effects linked to obesity and diabetes, albeit through different mechanisms from each other. In a recent study published in the Canadian Medical Association Journal, researchers found that potential side effects of aspartame are long-term weight gain and increased risk of obesity, as well as increased risk of diabetes, high blood pressure, and heart disease.10, In general, increased awareness of the health consequences of excess sugar consumption has fueled a dramatic uptick in the consumption of zero-calorie artificial sweeteners, such as aspartame. 1 pound. In addition, FDA has reaffirmed the safety of aspartame 26 times over the past 23 years for use in different types of foods and beverages. Having said all that, while I would like to take a more agnostic viewpoint, I just don’t see any benefit to the regular, long-term consumption of this artificial sweetener, especially given all the potential side effects of aspartame. Be that as it may, there’s compelling evidence that despite being metabolized in the upper intestine, gut bacteria still used and are affected by aspartame (perhaps via the byproducts of its metabolism), or maybe yet-to-be-determined mechanisms are involved.14, According to a new paper published in Molecules by researchers at Ben-Gurion University of Negev in Israel and Nanyang Technological University in Singapore, artificial sweeteners, including aspartame, are toxic to gut bacteria. According to one recent review study published in the journal Nutrition Reviews, for example, “The existing animal studies and limited human studies suggest aspartame and its metabolites, whether consumed in quantities significantly higher than the recommended safe dosage or within recommended safe levels, may disrupt the oxidant/antioxidant balance, induce oxidative stress, and damage cell membrane integrity, potentially affecting a variety of cells and tissues and causing a deregulation of cellular function, ultimately leading to systemic inflammation.”2, Chances are you’ve heard by now that chronic systemic inflammation is bad news. The blood-brain barrier, increasing its permeability and altering concentrations of neurotransmitters ( such as )... Way in the real world Home | FAQ 's | SITE Map | about | Contact | Terms use! Or fulfilled by Amazon that contain aspartame ( visit https: //www.nutrasweet.com for more information ) the U.S. when order... 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